Cause of fatal paralytic disease discovered

Scientists claim to have discovered the common cause of all forms of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease that paralyzes its victims.

The underlying disease process of ALS has long eluded doctors and prevented development of effective therapies. Now, a team at Northwestern University has for the first time discovered that the basis of the disorder is a broken down protein — identified as ubiquilin2 — recycling system in the neurons of the spinal cord and the brain.
Optimal functioning of the neurons relies on efficient recycling of protein building blocks in the cells. In ALS, that recycling system is broken. The cell can’t repair or maintain itself and becomes severely damaged.
In fact, ubiquilin2’s critical job is to recycle damaged or misfolded proteins in motor and cortical neurons and shuttle them off to be reprocessed. In people with ALS, it isn’t doing its job. As a result, the damaged proteins and ubiquilin2 accumulate and cause degeneration of the neurons. Cough may help during heart attack

FOOD FOR THOUGHT

New drug can extend life span of the obese

Sustaining the flickering hope that human aging might somehow be decelerated; researchers have found they can substantially extend the average life span of obese mice with a specially designed drug.

The drug, SRT-1720, protects the mice from the usual diseases of obesity by reducing the amount of fat in the liver and increasing sensitivity to insulin. These and other positive health effects enable the obese mice to live 44% longer, on average, than obese mice that did not receive the drug, according to a team of researchers led by Rafael de Cabo, a gerontologist at the National Institute on Aging.

Drugs closely related to SRT-1720 are now undergoing clinical trials in humans. The findings “demonstrate for the first time the feasibility of designing novel molecules that are safe and effective in promoting longevity and preventing multiple age-related diseases in mammals,” Dr de Cabo and colleagues write in the new journal Scientific Reports. Their conclusion supports claims that had been thrown in doubt by an earlier study that was critical of SRT-1720.

A drug that makes it cost-free to be obese may seem more a moral hazard than an incentive to good health. But the rationale behind the research is somewhat different: the researchers are trying to capture the benefits that allow mice on very low-calorie diets to live longer.

It just so happens that such benefits are much easier to demonstrate in mice under physiological stress like obesity than in normal mice. “The drugs could be used as a preventive , but I don’t think they will ever be an excuse to abuse your body,” said David Sinclair, a biologist at Harvard Medical School and co-chairman of the scientific advisory board of Sirtris, which developed SRT-1720.

What causes dark circles?

Dark circles under the eyes are caused by several factors, some of which are avoidable and can be prevented and treated easily.

The most common causes for dark circles are:

· Skin allergies:

The skin around the eyes is delicate and prone to eczema. Eyeliners, kohl and eye shadows trigger eczema. In some cases, the person may develop an allergy to his/her own oil or sweat and the skin usually appears coarse and wrinkled. Damage control includes exfoliating packs to even out the skin texture and gels for skin lightening.

· Sinusitis:

Sinus or nasal inflammation results in venous congestion, which can cause bruising around the bridge of the nose and eyes, giving rise to the appearance of dark circles. The condition is accompanied by headaches and patients constantly rub their eyes. Treating sinusitis or the allergy is the first step and this can reduce the dark circles in most cases. However, in some cases, eye packs and face packs may be also be required to treat the allergies.

Lack of nutrients:

Iron deficiency or lack of vitamin C can cause dark circles. Women with low haemoglobin count find dark circles becoming more prominent during their period. Skipping meals or consuming too much coffee can cause dark circles. Chronic illnesses like stomach or thyroid problems or sudden and severe weight loss cause dark circles. Identifying and correcting the deficiency often reverses dark circles. 

Fatigue, stress and lack of sleep:

These triggers are avoidable and the solution is to get more rest. But with increasing work and domestic responsibilities, many people do not get enough rest. Treating anxiety and forcing a break to de-stress is important. 

Now probiotic drugs sold over counter

Efficacy Not Proven, Warn Docs

Kill your diarrhoea with good bacteria. That’s the latest fad in healthcare. Almost every pharmaceutical company now has a brand of probiotic drug and some are even being commercially marketed off the counter.

Probiotics are foods that contain live bacteria. It is the bacteria and metabolites which they produce that give probiotics their health-promoting properties. The best known example is yogurt.

While some doctors are excited about chances of treating even severe intestinal disorders with probiotics, many say this is a huge money-spinner. Doctors are still assessing whether these drugs can be an alternative to antibiotics considering the increasing cases of antibiotic resistance in India.

WHAT IS PROBIOTIC?

• Live micro-organisms which when administered in adequate amounts confer a health benefit on the host, says World Health Organisation 

• It means introducing good live bacteria into your intestine to fight off bad bacteria 

• Lactic acid bacteria and bifidobacteria are the most common types of microbes used as probiotics 

Indian Council of Medical Research (ICMR)-appointed committee member and consultant gastroenterologist, Manipal Hospital, Dr Dinesh Kini, is part of the research team on probiotics. He says probiotics can’t be an alternative to antibiotics. “They’re a huge money-spinner that are pharmaceutically motivated and currently being used unscientifically. There is less scientific data on probiotics. It may, however, be used by travellers for diarrhoea, colitis, inflammatory bowel diseases and antibiotic-associated diarrhoea. It is not the wonder drug that it’s being projected to be,” he asserts.

“We need robust and randomized clinical trials to say with confidence that they have positive impact on health. The market is flooded with various brands of probiotics,” he adds.

“These are micro-organisms that colonize your intestine and remove harmful bacteria. The best natural probiotics are in yogurt and soy yogurt, which can be eaten on a regular basis even without a prescription. But people consume them less these days. So it is available in tablet and liquid forms. Research is being conducted to see its impact on colon cancer and urinary tract infections,” explains Dr B S Ravindra, consultant gastroenterologist, BGS Global Hospital.

There was a sudden increase in the prescription of probiotics recently. It was seen that they had a positive effect on patients who were under antibiotics for long and suffering from irritable bowel syndrome. Even patients who recurrently suffered from bouts of gastroenteritis showed good recovery.

“Use of probiotics has definitely increased. It’s true that yogurt and curds contain probiotics but those cannot be quantified. It is a great source of medication but I do not suggest that people buy it off the counter just for fitness. The quality and dosage of this live bacteria cannot be assured if it’s used without monitoring,” said Dr Ravishankar Bhat, consultant gastroenterologist, Apollo Hospitals.

AVAILABLE IN STORES

Pro-biotic yogurts and fortified supplements are available in almost all stores. I have tried them many times since they claim to have health benefits and assist in digestion but am not sure whether these claims are true.

THE BENEFITS

Experts agree that it may be helpful to those who have been consuming antibiotics for a long time. It may help in breeding good bacterial flora in the intestine and considered useful for irritable bowel syndrome.

GUIDELINES ON USAGE

ICMR released guidelines on the use of probiotics this year. It says: “Probiotics have been suggested to be associated with alleviation of lactose intolerance, prevention and cure of viral-, bacterial- and antibiotic- or radiotherapyinduced diarrhoea, anticarcinogenic effects and even blood cholesterol reduction. The optimism associated with probiotics is, however, counterbalanced by scepticism as many probiotic products in the market are unreliable in content and unproven clinically.’’

YES OR NO? Doctors are still assessing if these drugs can be an alternative to antibiotics