Scientists claim to have discovered the common cause of all forms of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease that paralyzes its victims.
The underlying disease process of ALS has long eluded doctors and prevented development of effective therapies. Now, a team at Northwestern University has for the first time discovered that the basis of the disorder is a broken down protein — identified as ubiquilin2 — recycling system in the neurons of the spinal cord and the brain.
Optimal functioning of the neurons relies on efficient recycling of protein building blocks in the cells. In ALS, that recycling system is broken. The cell can’t repair or maintain itself and becomes severely damaged.
In fact, ubiquilin2’s critical job is to recycle damaged or misfolded proteins in motor and cortical neurons and shuttle them off to be reprocessed. In people with ALS, it isn’t doing its job. As a result, the damaged proteins and ubiquilin2 accumulate and cause degeneration of the neurons. Cough may help during heart attack
The underlying disease process of ALS has long eluded doctors and prevented development of effective therapies. Now, a team at Northwestern University has for the first time discovered that the basis of the disorder is a broken down protein — identified as ubiquilin2 — recycling system in the neurons of the spinal cord and the brain.
Optimal functioning of the neurons relies on efficient recycling of protein building blocks in the cells. In ALS, that recycling system is broken. The cell can’t repair or maintain itself and becomes severely damaged.
In fact, ubiquilin2’s critical job is to recycle damaged or misfolded proteins in motor and cortical neurons and shuttle them off to be reprocessed. In people with ALS, it isn’t doing its job. As a result, the damaged proteins and ubiquilin2 accumulate and cause degeneration of the neurons. Cough may help during heart attack
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